![]() ![]() In individuals predisposed to develop allergic disease, the sequence of sensitization and clinical manifestations proceed as follows: eczema and respiratory disease (rhinitis and bronchospasm) in infants and children less than 5 years due to food sensitivity (milk, egg, soy, and wheat proteins) followed by respiratory disease (rhinitis and asthma) in older children and adults due to sensitivity to inhalant allergens (dust mite, mold, and pollen inhalants). The allergens chosen for testing often depend upon the age of the patient, history of allergen exposure, season of the year, and clinical manifestations. ![]() In vitro serum testing for IgE antibodies provides an indication of the immune response to allergens that may be associated with allergic disease. Testing for IgE antibodies may be used to help. Cashew allergy diagnosis: A two-step algorithm leads to fewer oral food challenges. Clinical manifestations of immediate hypersensitivity (allergic) diseases are caused by the release of proinflammatory mediators (histamine, leukotrienes, and prostaglandins) from IgE-sensitized effector cells (mast cells and basophils) when cell-bound IgE antibodies interact with an allergen. Food allergen mix 77 (fx77) contains kiwi, cashew nut, hazelnut, tomato and sesame seed IgE antibodies. Clinicians are seeing a growing number of cashew nut sensitized patients 1, 2.The clinical relevance of cashew nut sensitization is high as consumption of this nut can cause severe allergic reactions 3. ![]()
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